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When tannins interact with the proteins in your saliva, they bind together and cause that drying, grippy feeling. Different grape varieties naturally contain varying levels of tannins. For example, red wines made from grapes like Cabernet Sauvignon and Nebbiolo are known for their high tannin content, contributing to a more astringent profile. A little astringency can add structure, complexity, and aging potential, but too much can feel harsh or unbalanced. Winemakers manage astringency through grape selection, fermentation methods, and aging choices. 
Wines with pronounced astringency can be excellent with rich, fatty foods because the drying sensation cleanses the palate, preparing it for the next bite.